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KMID : 0525619980030010090
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1998 Volume.3 No. 1 p.90 ~ p.100
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The metabolic mechanism of C - 14 labeled chitosan in mice
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Kim KY
KimYH/Kim HK/Bom HS/Kim JY/Yoshikazu Nishimura/Kim JW/Oh CS/Park RD/Lee HC/Kang MI/Roh YB
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Abstract
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Chitin is exists in the exoskeleton of crustaceans and chitosan can be obtained by deacetylation of chitin. As chitosan has a chelating characteristics, it was used radiostrontium chelator in the rats and mice. It also can be used as a healthy food and medicine. The purpose of the prsent study is to investigate the chitosan distribution and excretory route of 14C-chitosan in the animal body. 14C-chitosan was prepared and intravenously administered to the vein of mice and also intraorally ingested. The body distribution of chitosan was studied by autoradiography and the urinary excretion was counted. C-14 label chitosan was showed high distribution in the liver. And 10~20% of chitosan was excreted to the urine through kidney within few days. Chitosan was gathered into gromerulus in kidney and excreted from three hours. It was concluded that chitosan has no target organs and liver distribution is a sort of only passing route for the urinary excretion by way of kidney.
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KEYWORD
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